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Article

Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?

The Clinical journal of pain - 1 Mar 2014

Fernández-de-las-Peñas César, Peñacoba-Puente Cecilia, Cigarán-Méndez Margarita, Díaz-Rodríguez Lourdes, Rubio-Ruiz Belén, Arroyo-Morales Manuel

Abstract excerpt

OBJECTIVE: Stress can play an important role in etiology of fibromyalgia syndrome (FMS) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. The current study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase), and immune (IgA) systems in women...

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Source

Identifiers

PMID: 24503977
DOI: 10.1097/AJP.0b013e3182928da0

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?PMID 24503977Read ↗

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