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Article

The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.

Clinical and experimental rheumatology - 1 Jan 2000

Cohen H, Neumann L, Glazer Y, Ebstein R P, Buskila D

Abstract excerpt

OBJECTIVES: Fibromyalgia syndrome (FM) is an idiopathic chronic pain syndrome characterised by widespread nonarticular musculoskeletal pain, generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities, accompanied by a constellation of symptoms that include fatigue and disturbances of sleep and mood. Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing...

Topics

Adult
Aged
Alleles
Analysis of Variance
Catechol O-Methyltransferase
Chi-Square Distribution
Female
Fibromyalgia
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 20074440

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.PMID 20074440Read ↗

Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.Semantic proximity Read ↗

The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?Semantic proximity Read ↗

Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.Semantic proximity Read ↗

UNRAVELING THE CLINICO-GENETIC ASSOCIATION OF CATECHOL-O-METHYLTRANSFERASE-RS4680 G>A GENE POLYMORPHISM IN WOMEN WITH FIBROMYALGIA SYNDROME.Semantic proximity Read ↗

Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val¹⁵⁸met and fibromyalgia.Semantic proximity Read ↗

Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.Semantic proximity Read ↗

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Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.Semantic proximity Read ↗

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