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Article

The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.

Clinical and experimental rheumatology - 1 Jan 2000

Cohen H, Neumann L, Glazer Y, Ebstein R P, Buskila D

Abstract excerpt

OBJECTIVES: Fibromyalgia syndrome (FM) is an idiopathic chronic pain syndrome characterised by widespread nonarticular musculoskeletal pain, generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities, accompanied by a constellation of symptoms that include fatigue and disturbances of sleep and mood. Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing...

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Source

Identifiers

PMID: 20074440

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.PMID 20074440Read ↗

Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.Semantic proximity Read ↗

The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?Semantic proximity Read ↗

Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.Semantic proximity Read ↗

UNRAVELING THE CLINICO-GENETIC ASSOCIATION OF CATECHOL-O-METHYLTRANSFERASE-RS4680 G>A GENE POLYMORPHISM IN WOMEN WITH FIBROMYALGIA SYNDROME.Semantic proximity Read ↗

Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val¹⁵⁸met and fibromyalgia.Semantic proximity Read ↗

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Association of polymorphism of the enzyme catechol-o-methyltransferase with fibromialgic syndrome and its clinical repercussionsSemantic proximity Read ↗

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Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia.Semantic proximity Read ↗

Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.Semantic proximity Read ↗

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