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Article

Endothelin in polycystic kidney disease.

Contributions to nephrology - 1 Jan 2011

Chang Ming-Yang, Ong Albert C M

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease in man and is caused by germline mutations in PKD1 or PKD2. Affected patients develop progressively enlarged kidneys due to the growth of multiple renal epithelial cysts. Several studies have demonstrated marked intrafamilial phenotypic variability in PKD1 or PKD2 pedigrees, indicating the importance of nonallelic...

Read the complete abstract on PubMed

Topics

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Kidney Tubules

Share to Polycystic Kidney, Autosomal Dominant

Share to Polymorphism, Single Nucleotide

Share to Receptor, Endothelin A

Source

Identifiers

PMID: 21894000
DOI: 10.1159/000328701

Genes

PKD1
PKD2
EDN1
EDNRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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