Article
Endothelial nitric oxide synthase affects the progression of autosomal dominant polycystic kidney disease.
Kidney & blood pressure research - 1 Jan 2002
Reiterová Jana, Merta Miroslav, Tesar Vladimir, Stekrová Jitka
Abstract excerpt
BACKGROUND/AIM: The phenotypic variability of autosomal dominant polycystic kidney disease (ADPKD) cannot be explained only by various mutations of two known genes (PKD1 and PKD2), but the influence of other unknown factors should also be considered. Impairment of endothelial function has been observed in ADPKD patients. Our study tried to verify the hypothesis that endothelial nitric oxide synthase (ecNOS) gene...
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