Article
Influence of endothelin-1 gene polymorphisms on the progression of autosomal dominant polycystic kidney disease.
Kidney & blood pressure research - 1 Jan 2006
Reiterová J, Merta M, Stekrová J, Cabartová Z, Cibulka R, Maixnerová D, Rysavá R, Ríhová Z, Tesar V, Motán J
Abstract excerpt
BACKGROUND/AIM: A significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). The variability cannot be fully explained by the genetic heterogeneity of the disease. Endothelin-1 (ET-1) has been suggested to be a major promoting factor in renal diseases. The role of the ET-1 gene locus (EDN1) in the renal function in the general nondiabetic population was evaluated. We...
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