Article
APC and the three-hit hypothesis.
Oncogene - 8 Jan 2009
Segditsas S, Rowan A J, Howarth K, Jones A, Leedham S, Wright N A, Gorman P, Chambers W, Domingo E, Roylance R R, Sawyer E J, Sieber O M, Tomlinson I P M
Abstract excerpt
The seminal 'two-hit hypothesis' implicitly assumes that bi-allelic tumour suppressor gene (TSG) mutations cause loss of protein function. All subsequent events in that tumour therefore take place on an essentially null background for that TSG protein. We have shown that the two-hit model requires modification for the APC TSG, because mutant APC proteins probably retain some function and the two hits are...
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