Article
The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response.
Schizophrenia research - 1 Nov 2011
Lett Tristram A P, Tiwari Arun K, Meltzer Herbert Y, Lieberman Jeffrey A, Potkin Steven G, Voineskos Aristotle N, Kennedy James L, Müller Daniel J
Abstract excerpt
Neurexin-1 (NRXN1) modulates recruitment of NMDA receptors. Furthermore, clozapine reduces hyperactivity of NMDA receptors. Thus, regulation of the NRXN1 gene may mediate the efficacy of clozapine at reducing cortical hyperactivity. We examined the putative functional SNP, rs1045881, for association with schizophrenia, and the potential role of this SNP in clozapine response. The rs1045881 variant was not...
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