Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes.

Pharmacogenetics and genomics - 1 May 2015

Mitjans Marina, Catalán Rosa, Vázquez Mireia, González-Rodríguez Alex, Penadés Rafael, Pons Alexandre, Massana Guillem, Munro Janet, Arranz Maria J, Arias Bárbara

Abstract excerpt

Clozapine is an atypical antipsychotic drug known as being more effective compared with traditional antipsychotics for patients with poor response or resistance to treatment. It has been demonstrated that clozapine modulates hypothalamic-pituitary-adrenal activity and affects central brain-derived neurotrophic factor levels, which could explain part of its therapeutic efficacy. In this study, we investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Pituitary-Adrenal System

Share to Protein-Tyrosine Kinases

Share to Receptor, trkB

Share to Schizophrenia

Share to Tacrolimus Binding Proteins

Source

Identifiers

PMID: 25751398
DOI: 10.1097/FPC.0000000000000132

Genes

NTRK2
FKBP5
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes.PMID 25751398Read ↗

Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an updateSemantic proximity Read ↗

Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.Semantic proximity Read ↗

Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.Semantic proximity Read ↗

FKBP5 polymorphisms and antidepressant response in geriatric depression.Semantic proximity Read ↗

Pharmacogenetics of Antipsychotic Drug Treatment: Update and Clinical ImplicationsSemantic proximity Read ↗

Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine.Semantic proximity Read ↗

Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.Semantic proximity Read ↗

A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychoticsSemantic proximity Read ↗

Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia.Semantic proximity Read ↗

Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.Semantic proximity Read ↗

Pharmacogenetics analysis of serotonin receptor gene variants and clinical response to risperidone in Han Chinese schizophrenic patients.Semantic proximity Read ↗

Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.