Article
Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition.
Biological psychiatry - 1 Jan 2008
Hong L Elliot, Wonodi Ikwunga, Stine O Colin, Mitchell Braxton D, Thaker Gunvant K
Abstract excerpt
BACKGROUND: Neuregulin 1 (NRG1) is one of the leading candidate genes in schizophrenia. Rodents with NRG1 knock-out showed significantly impaired prepulse inhibition (PPI) in the original report linking NRG1 to schizophrenia. A widely used surrogate measure of psychosis in animal models, PPI is considered a schizophrenia endophenotype. We hypothesized that if NRG1 influences PPI in rodents, then it should have a...
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