Article
Maternal and paternal environmental risk factors, metabolizing GSTM1 and GSTT1 polymorphisms, and congenital heart disease.
The American journal of cardiology - 1 Dec 2011
Cresci Monica, Foffa Ilenia, Ait-Ali Lamia, Pulignani Silvia, Gianicolo Emilio Antonio Luca, Botto Nicoletta, Picano Eugenio, Andreassi Maria Grazia
Abstract excerpt
Congenital heart defects (CHDs) are the most prevalent of all birth malformations arising from the complex interplay of environmental exposures and genes. Modifiable environmental risk factors are still largely unknown, especially for paternal exposure. The aim of the present study was to examine the association between the environmental exposures of both parents and CHD risk and to explore the modification...
Topics
- Adult
- DNA
- Female
- Genotype
- Glutathione Transferase
- Heart Defects, Congenital
- Humans
- Incidence
- Infant, Newborn
- Italy
- Male