Article
Modification of the association between maternal smoke exposure and congenital heart defects by polymorphisms in glutathione S-transferase genes.
Scientific reports - 12 Oct 2015
Li Xiaohong, Liu Zhen, Deng Ying, Li Shengli, Mu Dezhi, Tian Xiaoxian, Lin Yuan, Yang Jiaxiang, Li Jun, Li Nana, Wang Yanping, Chen Xinlin, Deng Kui, Zhu Jun
Abstract excerpt
Congenital heart defects (CHDs) arise through various combinations of genetic and environmental factors. Our study explores how polymorphisms in the glutathione S-transferase (GST) genes affect the association between cigarette smoke exposure and CHDs. We analysed 299 mothers of children with CHDs and 284 mothers of children without any abnormalities who were recruited from six hospitals. The hair nicotine...
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