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Article

Maternal environmental exposure, infant GSTP1 polymorphism, and risk of isolated congenital heart disease.

Pediatric cardiology - 1 Feb 2013

Cresci Monica, Foffa Ilenia, Ait-Ali Lamia, Pulignani Silvia, Kemeny Alessandra, Gianicolo Emilio Antonio Luca, Andreassi Maria Grazia

Abstract excerpt

The GSTP1 gene, highly expressed early in fetal life, is the most abundant phase 2 xenobiotic metabolism enzyme in a human placenta. Fetal inherited GSTP1 Ile105Val polymorphism may modify the metabolism and excretion of xenobiotics from fetal tissue and increase the risk of congenital heart disease (CHD). This study aimed to analyze the joint effects of GSTP1 genetic polymorphism (Ile105Val) and maternal...

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Source

Identifiers

PMID: 22815093
DOI: 10.1007/s00246-012-0436-z

Genes

GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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