Article
Characterization and functional analyses of the human G protein-coupled receptor kinase 4 gene promoter.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2008
Hasenkamp Sandra, Telgmann Ralph, Staessen Jan A, Hagedorn Claudia, Dördelmann Corinna, Bek Martin, Brand-Herrmann Stefan-Martin, Brand Eva
Abstract excerpt
The G protein-coupled receptor kinase 4 is involved in renal sodium handling and blood pressure regulation. Missense variants have already been tested functionally and are associated with hypertension, but no data on promoter analyses are yet available. We scanned 94 hypertensive white subjects for genetic variation and performed promoter reporter gene analyses in HEK293T, COS7, and SaOs-2 cells. Transient...
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