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Article

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12.

PloS one - 1 Jan 2008

Long Jarukit Edward, Renzette Nicholas, Centore Richard C, Sandler Steven J

Abstract excerpt

BACKGROUND: Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response. The RecA-DNA filament is an allosteric effector of LexA auto-proteolysis. LexA is the repressor of the SOS Response. Not all RecA-DNA filaments, however, lead to an SOS Response. Certain recA mutants...

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Identifiers

PMID: 19116657
DOI: 10.1371/journal.pone.0004100
PMCID: PMC2605550

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Source receipt: pubmed, retrieved 7 Sept 2026.

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