Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.

doi:10.1006/jmbi.1997.1531

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Article

Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.

Journal of molecular biology - 20 Feb 1998

Konola J T, Guzzo A, Gow J B, Walker G C, Knight K L

Abstract excerpt

In Escherichia coli, RecA-mediated cleavage of LexA repressor is a key regulatory event required for expression of SOS genes involved in the repair of DNA damage. RecA also mediates the cleavage of UmuD protein to UmuD, a form active in SOS mutagenesis. To determine whether LexA and UmuD have com...

Topics

Bacterial Proteins
Binding Sites
DNA-Directed DNA Polymerase
Escherichia coli Proteins
Models, Molecular
Mutation
Proline
Protein Conformation
Rec A Recombinases
Serine Endopeptidases

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