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Article

Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.

Journal of molecular biology - 20 Feb 1998

Konola J T, Guzzo A, Gow J B, Walker G C, Knight K L

Abstract excerpt

In Escherichia coli, RecA-mediated cleavage of LexA repressor is a key regulatory event required for expression of SOS genes involved in the repair of DNA damage. RecA also mediates the cleavage of UmuD protein to UmuD, a form active in SOS mutagenesis. To determine whether LexA and UmuD have common binding determinants on RecA, we have compared the ability of several recA mutants to function in the cleavage of...

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PMID: 9512712
DOI: 10.1006/jmbi.1997.1531

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Research trail→

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Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.PMID 9512712Read ↗

Analysis of recA mutants with altered SOS functions.Semantic proximity Read ↗

Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis.Semantic proximity Read ↗

Proteolytic activation of UmuD and MucA proteins for SOS mutagenesis.Semantic proximity Read ↗

RecA protein of Escherichia coli has a third essential role in SOS mutator activity.Semantic proximity Read ↗

Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction.Semantic proximity Read ↗

Mutant LexA proteins with an increased rate of in vivo cleavage.Semantic proximity Read ↗

Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12.Semantic proximity Read ↗

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12.Semantic proximity Read ↗

Regulation of UmuD cleavage: role of the amino-terminal tail.Semantic proximity Read ↗

Mutations at Pro67 in the RecA protein P-loop motif differentially modify coprotease function and separate coprotease from recombination activities.Semantic proximity Read ↗

In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage.Semantic proximity Read ↗

Molecular design and functional organization of the RecA protein.Semantic proximity Read ↗

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