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Article

Interaction of adenovirus VA RNAl with the protein kinase DAI: nonequivalence of binding and function.

Cell - 1 Jun 1990

Mellits K H, Kostura M, Mathews M B

Abstract excerpt

Adenovirus VA RNAL maintains protein synthesis by preventing activation of the double-stranded RNA (dsRNA)-dependent protein kinase DAI. There appears to be a single binding site for dsRNA on DAI, and this site is blocked by VA RNAl. VA RNAl binds to purified DAI and can be cross-linked to the enzyme by UV irradiation. To determine the relationship between DAI binding and VA RNAl structure and function, we...

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Identifiers

PMID: 2188737
DOI: 10.1016/0092-8674(90)90194-j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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