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Article

Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition.

PloS one - 1 Jan 2017

Dzananovic Edis, Astha, Chojnowski Grzegorz, Deo Soumya, Booy Evan P, Padilla-Meier Pauline, McEleney Kevin, Bujnicki Janusz M, Patel Trushar R, McKenna Sean A

Abstract excerpt

Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation factor 2α and attenuates viral protein translation. Adenovirus can evade this line of defence through transcription of a non-coding RNA, VAI, an inhibitor of PKR....

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PMID: 29053745
DOI: 10.1371/journal.pone.0186849
PMCID: PMC5650172

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Source receipt: pubmed, retrieved 7 Sept 2026.

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