Article
Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I.
RNA (New York, N.Y.) - 1 Sept 1996
Ma Y, Mathews M B
Abstract excerpt
The small (160 nt) adenovirus RNA, VA RNAI, antagonizes the activation of the cellular protein kinase PKR (also known as DAI), a key regulator of gene expression. VA RNA consists of two stems separated by a complex region, the central domain, that is essential for its function. A notable feature...
Topics
- Adenoviruses, Human
- Base Sequence
- Binding Sites
- Conserved Sequence
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nucleic Acid Conformation
- Protein Serine-Threonine Kinases
- RNA, Small Nuclear
- RNA, Viral