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Article

Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I.

RNA (New York, N.Y.) - 1 Sept 1996

Ma Y, Mathews M B

Abstract excerpt

The small (160 nt) adenovirus RNA, VA RNAI, antagonizes the activation of the cellular protein kinase PKR (also known as DAI), a key regulator of gene expression. VA RNA consists of two stems separated by a complex region, the central domain, that is essential for its function. A notable feature of the central domain is a pair of tetranucleotides, GGGU and ACCC, which are mutually complementary and...

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PMID: 8809020
PMCID: PMC1369428

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