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Article

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.

Cell host & microbe - 9 Nov 2016

Thapa Roshan J, Ingram Justin P, Ragan Katherine B, Nogusa Shoko, Boyd David F, Benitez Asiel A, Sridharan Haripriya, Kosoff Rachelle, Shubina Maria, Landsteiner Vanessa J, Andrake Mark, Vogel Peter, Sigal Luis J, tenOever Benjamin R, Thomas Paul G, Upton Jason W, Balachandran Siddharth

Abstract excerpt

Influenza A virus (IAV) is an RNA virus that is cytotoxic to most cell types in which it replicates. IAV activates the host kinase RIPK3, which induces cell death via parallel pathways of necroptosis, driven by the pseudokinase MLKL, and apoptosis, dependent on the adaptor proteins RIPK1 and FADD. How IAV activates RIPK3 remains unknown. We report that DAI (ZBP1/DLM-1), previously implicated as a cytoplasmic DNA...

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Source

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Identifiers

PMID: 27746097
DOI: 10.1016/j.chom.2016.09.014
PMCID: PMC5687825

Genes

RIPK3
MLKL
RIPK1
FADD
ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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