Article
The 5'-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex.
Nucleic acids research - 1 Nov 2009
Xu Ning, Gkountela Sofia, Saeed Khalid, Akusjärvi Göran
Abstract excerpt
Human Adenovirus type 5 encodes two short RNA polymerase III transcripts, the virus-associated (VA) RNAI and VA RNAII, which can adopt stable hairpin structures that resemble micro-RNA precursors. The terminal stems of the VA RNAs are processed into small RNAs (mivaRNAs) that are incorporated into RISC. It has been reported that VA RNAI has two transcription initiation sites, which produce two VA RNAI species; a...
Topics
- Adenoviruses, Human
- Mutation
- Phosphorylation
- RNA Interference
- RNA, Viral
- RNA-Induced Silencing Complex
- Ribonuclease III