Article
In vitro analysis of virus-associated RNA I (VAI RNA): inhibition of the double-stranded RNA-activated protein kinase PKR by VAI RNA mutants correlates with the in vivo phenotype and the structural integrity of the central domain.
Journal of virology - 1 Jul 1994
Ghadge G D, Malhotra P, Furtado M R, Dhar R, Thimmapaya B
Abstract excerpt
Adenoviruses use the virus-encoded virus-associated RNA (VAI RNA) as a defense against cellular antiviral response by blocking the activation of the interferon-induced, double-stranded RNA-activated protein kinase PKR. The structure of VAI RNA consists of two long, imperfectly base-paired duplex...
Topics
- Adenoviruses, Human
- Base Sequence
- Enzyme Activation
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Phenotype
- Phosphorylation
- Protein Serine-Threonine Kinases
- RNA, Double-Stranded
- RNA, Viral
- eIF-2 Kinase