Article
The secondary structure of the adenovirus-2 L4 polyadenylation domain: evidence for a hairpin structure exposing the AAUAAA signal in its loop.
Journal of molecular biology - 5 May 1995
Sittler A, Gallinaro H, Jacob M
Abstract excerpt
The secondary structure of the adenovirus-2 L4 polyadenylation domain was established using enzymatic attacks and chemical modifications. This domain is characterized by the co-existence of several variants including stem-loop structures of low stability such that its secondary structure is clearly distinct from that of the upstream sequence which harbors large stable hairpin structures. The L4 polyadenylation...
Topics
- Adenovirus E3 Proteins
- Adenoviruses, Human
- Base Sequence
- Computer Simulation
- Endoribonucleases
- HeLa Cells
- Humans
- Magnesium
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
