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Article

Suppression of RNA interference by adenovirus virus-associated RNA.

Journal of virology - 1 Aug 2005

Andersson M Gunnar, Haasnoot P C Joost, Xu Ning, Berenjian Saideh, Berkhout Ben, Akusjärvi Göran

Abstract excerpt

We show that human adenovirus inhibits RNA interference (RNAi) at late times of infection by suppressing the activity of two key enzyme systems involved, Dicer and RNA-induced silencing complex (RISC). To define the mechanisms by which adenovirus blocks RNAi, we used a panel of mutant adenoviruses defective in virus-associated (VA) RNA expression. The results show that the virus-associated RNAs, VA RNAI and VA...

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Identifiers

PMID: 16014917
DOI: 10.1128/JVI.79.15.9556-9565.2005
PMCID: PMC1181602

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Source receipt: pubmed, retrieved 7 Sept 2026.

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