Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies.

doi:10.1016/j.bbmt.2012.09.014

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Article

Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Feb 2013

Espinoza J Luis, Takami Akiyoshi, Onizuka Makoto, Morishima Yasuo, Fukuda Takahiro, Kodera Yoshihisa, Akiyama Hideki, Miyamura Koichi, Mori Takehiko, Nakao Shinji

Abstract excerpt

PTPN22 is a critical negative regulator of T cell responses. Its promoter gene variant (rs2488457, -1123G>C) has been reported to be associated with autoimmune diseases. This study analyzed the impact of the PTPN22 variant on transplantation outcomes in a cohort of 663 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor...

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Identifiers

PMID: 23025987
DOI: 10.1016/j.bbmt.2012.09.014

Genes

PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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