Article
The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination.
PloS one - 1 Jan 2011
Chico Lidia, Ciudad Toni, Hsu Min, Lue Neal F, Larriba Germán
Abstract excerpt
The heterodimeric Ku complex has been shown to participate in DNA repair and telomere regulation in a variety of organisms. Here we report a detailed characterization of the function of Ku70 in the diploid fungal pathogen Candida albicans. Both ku70 heterozygous and homozygous deletion mutants have a wild-type colony and cellular morphology, and are not sensitive to MMS or UV light. Interestingly, we observed...
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