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Article

Pharmacogenetics of the effects of colesevelam on colonic transit in irritable bowel syndrome with diarrhea.

Digestive diseases and sciences - 1 May 2012

Wong Banny S, Camilleri Michael, Carlson Paula J, Odunsi-Shiyanbade Suwebatu, McKinzie Sanna, Busciglio Irene, Burton Duane, Zinsmeister Alan R

Abstract excerpt

BACKGROUND: Protein products of klothoβ (KLB) and fibroblast growth factor receptor 4 (FGFR4) impact fibroblast growth factor 19-mediated feedback inhibition of hepatic bile acid (BA) synthesis. Variants of KLB and FGFR4 influence colonic transit (CT) in diarrhea-predominant irritable bowel syndrome (IBS-D). AIM: The purpose of this study was to test the hypothesis that colesevelam's slowing effects on CT in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22271411
DOI: 10.1007/s10620-012-2035-5
PMCID: PMC3809827

Genes

FGFR4
KLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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