Article
Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Apr 2015
Maehlen Marthe T, Olsen Inge C, Andreassen Bettina K, Viken Marte K, Jiang Xia, Alfredsson Lars, Källberg Henrik, Brynedal Boel, Kurreeman Fina, Daha Nina, Toes Rene, Zhernakova Alexandra, Gutierrez-Achury Javier, de Bakker Paul I W, Martin Javier, Teruel María, Gonzalez-Gay Miguel A, Rodríguez-Rodríguez Luis, Balsa Alejandro, Uhlig Till, Kvien Tore K, Lie Benedicte A
Abstract excerpt
OBJECTIVE: Certain HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) are associated with rheumatoid arthritis (RA). Our objective was to examine the combined effect of these associated variants, calculated as a cumulative genetic risk score (GRS) on RA predisposition, as well as the number of autoantibodies (none, one or two present). METHOD: We calculated four GRSs in 4956 patients and 4983 controls...
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