Article
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
Arthritis and rheumatism - 1 Mar 2012
Prahalad Sampath, Thompson Susan D, Conneely Karen N, Jiang Yunxuan, Leong Traci, Prozonic Jennifer, Brown Milton R, Ponder Lori A, Angeles-Han Sheila T, Vogler Larry B, Kennedy Christine, Wallace Carol A, Wise Carol A, Punaro Marilynn, Reed Ann, Park Jane L, Mellins Elizabeth D, Zeft Andrew S, Bohnsack John F, Glass David N
Abstract excerpt
OBJECTIVE: Associations between shared epitope (SE)-encoding HLA-DRB1 alleles and rheumatoid arthritis (RA) are well established. However, only a limited number of studies have investigated these alleles in patients with childhood-onset RA, which is defined as rheumatoid factor- and/or anti-citrullinated protein antibody-positive juvenile idiopathic arthritis. The aims of this study were to investigate the...
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