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Article

Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.

Current molecular medicine - 1 Jan 2015

Shiwaku H, Okazawa H

Abstract excerpt

Impaired DNA damage repair is a common pathological endophenotype of some types of neurodegenerative diseases, intellectual disabilities, and psychiatric diseases. Dysfunctional DNA repair and DNA damage, including DNA double-stranded breaks, are linked to transcriptional dysfunction and abnormal DNA methylation. Impaired DNA repair in neural stem cells leads to microcephaly or cerebellar ataxia. Furthermore, DNA...

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PMID: 25732151
DOI: 10.2174/1566524015666150303002556

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