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Article

A neurological phenotype in mice with DNA repair gene Ercc1 deficiency.

DNA repair - 1 Feb 2008

Lawrence Nicola J, Sacco Joseph J, Brownstein David G, Gillingwater Thomas H, Melton David W

Abstract excerpt

Transcription-coupled repair of endogenous DNA damage appears crucial for the maintenance of the central and peripheral nervous systems. Ercc1 is essential for nucleotide excision repair and is also involved in recombination repair and the repair of interstrand cross-links. We have investigated the neurological phenotype of Ercc1-deficient mice where the liver dysfunction has been corrected by an Ercc1 transgene...

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Source

Identifiers

PMID: 18221731
DOI: 10.1016/j.dnarep.2007.10.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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