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Article

Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse.

Mechanisms of ageing and development - 1 Jan 2000

Spoor Marcella, Nagtegaal A Paul, Ridwan Yanto, Borgesius Nils Z, van Alphen Bart, van der Pluijm Ingrid, Hoeijmakers Jan H J, Frens Maarten A, Borst J Gerard G

Abstract excerpt

Age-related loss of hearing and vision are two very common disabling conditions, but the underlying mechanisms are still poorly understood. Damage by reactive oxygen species and other reactive cellular metabolites, which in turn may damage macromolecules such as DNA, has been implicated in both processes. To investigate whether DNA damage can contribute to age-related hearing and vision loss, we investigated...

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Identifiers

PMID: 22257940
DOI: 10.1016/j.mad.2011.12.003

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