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Article

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

1 May 2016

Abstract excerpt

The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus between DNA damage accumulation, aging, and PD by assessing aging-related DNA repair pathways in laboratory animal models and humans. We demonstrate that dermal fibroblasts from PD patients...

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PMID: 27210754
DOI: 10.1016/j.celrep.2016.04.071

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