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The Ercc1−/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration

27 Nov 2024

Abstract excerpt

Abstract Age‐related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage. DNA damage is one hallmark of aging implicated in loss of organ function. Genome instability has been associated with several disorders that result in premature...

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PMID: 39604117
DOI: 10.1111/acel.14419

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