Article
Mutational analysis of a signal sequence required for protein secretion in Leishmania major.
Molecular and biochemical parasitology - 1 Dec 1993
Tobin J F, Wirth D F
Abstract excerpt
In eukaryotes, amino-terminal extensions, signal sequences, mediate the translocation of lysosomal, membrane and secreted proteins into the lumen of the endoplasmic reticulum (ER). Structure/function studies indicate that eukaryotic signal sequences are composed of 3 distinct domains, a positively charged amino-terminal domain, a central hydrophobic domain, and a polar carboxy-terminal domain. In an attempt to...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA, Protozoan
- Interferon-gamma
- Leishmania major
- Mice
- Molecular Sequence Data
- Phenotype
- Protein Sorting Signals