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Article

Functional tolerance of the human immunodeficiency virus type 1 envelope signal peptide to mutations in the amino-terminal and hydrophobic regions.

Journal of virology - 1 Aug 1992

Ellerbrok H, D'Auriol L, Vaquero C, Sitbon M

Abstract excerpt

We demonstrated that the leader sequence of the human immunodeficiency virus type 1 envelope functions as signal peptide (SP) despite low scoring in a prediction program. As expected for SP, the hydrophobic core (HC) is essential, and no other sequence could compensate for HC deletion. Contrary to other SPs, major substitutions in the HC, such as introduction of basic, polar, or alpha-helix-breaking residues,...

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Identifiers

PMID: 1629966
DOI: 10.1128/JVI.66.8.5114-5118.1992
PMCID: PMC241382

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Source receipt: pubmed, retrieved 7 Sept 2026.

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