Article
Functional tolerance of the human immunodeficiency virus type 1 envelope signal peptide to mutations in the amino-terminal and hydrophobic regions.
Journal of virology - 1 Aug 1992
Ellerbrok H, D'Auriol L, Vaquero C, Sitbon M
Abstract excerpt
We demonstrated that the leader sequence of the human immunodeficiency virus type 1 envelope functions as signal peptide (SP) despite low scoring in a prediction program. As expected for SP, the hydrophobic core (HC) is essential, and no other sequence could compensate for HC deletion. Contrary t...
Topics
- Amino Acid Sequence
- Animals
- Dogs
- Genes, env
- HIV-1
- Microsomes
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Pancreas
- Plasmids
- Protein Biosynthesis
- Protein Sorting Signals
- Rabbits
- Reticulocytes
- Retroviridae
- Transcription, Genetic
- Viral Envelope Proteins