Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypervariable region 5'-flanking [Leu A3]insulin gene of insulin Tochigi is different from those of insulin Wakayama I,II.

Diabetes research and clinical practice - 1 Mar 1990

Awata T, Iwamoto Y, Matsuda A, Kuzuya T

Abstract excerpt

Three families with abnormal insulinemia have been reported in Japan and sequencing analysis revealed that they had the same point mutation in one allele of the insulin genes causing [Leu A3]insulin. To estimate whether or not this same mutation came from a common ancestor we determined the sequence of the hypervariable region 5'-flanking the third [Leu A3]insulin allele (insulin Tochigi). This region is composed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Genes
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Repetitive Sequences, Nucleic Acid

Share to Restriction Mapping

Source

Identifiers

PMID: 2187661
DOI: 10.1016/0168-8227(90)90115-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypervariable region 5'-flanking [Leu A3]insulin gene of insulin Tochigi is different from those of insulin Wakayama I,II.PMID 2187661Read ↗

Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.Semantic proximity Read ↗

Systematic search for single nucleotide polymorphisms in the insulin gene: evidence for a high frequency of -23T-->A in Japanese subjects.Semantic proximity Read ↗

Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome.Semantic proximity Read ↗

Detection of mutations in the human insulin gene by single strand conformation polymorphisms.Semantic proximity Read ↗

A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).Semantic proximity Read ↗

Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.Semantic proximity Read ↗

Allelic divergence in the human insulin gene provides evidence for intragenic recombination events in the non-coding regions: evidence for existence of new alleles.Semantic proximity Read ↗

[Study on base insertion/deletion of CAG-rich region in insulin receptor substrate-1 5'-regulatory sequence].Semantic proximity Read ↗

Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Restriction fragment length polymorphisms near the islet amyloid polypeptide gene in Japanese subjects.Semantic proximity Read ↗

Mutagenesis of the three conserved valine residues: consequence on the foldability of insulin.Semantic proximity Read ↗

Islet amyloid polypeptide (IAPP) gene analysis in a Japanese diabetic with marked islet amyloid deposition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.