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Article

Mutagenesis of the three conserved valine residues: consequence on the foldability of insulin.

Biochimica et biophysica acta - 1 Jun 2004

Guo Zhan-Yun, Wang Shuai, Tang Yue-Hua, Feng You-Min

Abstract excerpt

Natural polypeptide chain usually can spontaneously fold into tightly compact native structure. This capability is the so-called foldability. However, how the foldability is encoded in the polypeptide chain is still poorly understood. The structure of insulin has been well solved and extensively investigated. Therefore, insulin provides a good model for investigating the role of individual residue to the sequence...

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PMID: 15158717
DOI: 10.1016/j.bbapap.2004.02.003

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PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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