Article
Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome.
Diabetes - 1 Oct 1995
Uchigata Y, Tokunaga K, Nepom G, Bannai M, Kuwata S, Dozio N, Benson E A, Ronningen K S, Spinas G A, Tadokoro K
Abstract excerpt
The insulin autoimmune syndrome (IAS), or Hirata's disease, is characterized by the combination of fasting hypoglycemia, high concentration of total serum immunoreactive insulin, and presence of autoantibodies to native human insulin in serum. Autoantibody production is classified as monoclonal o...
Topics
- Adult
- Aged
- Alleles
- Autoimmune Diseases
- Fasting
- Female
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Hypoglycemia
- Insulin