Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.

doi:10.2337/diacare.9.4.365

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Article

Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.

Diabetes care - 1 Jan 2000

Aoyama N, Nakamura T, Doi K, Baba S, Takahashi R, Sugiyama T

Abstract excerpt

Polymorphism in the 5'-flanking region of the human insulin gene in 149 unrelated Japanese subjects [77 with non-insulin-dependent diabetes mellitus (NIDDM), 17 with insulin-dependent diabetes mellitus (IDDM), and 55 controls] was analyzed with Southern blot hybridization. We used the size of the hybridized fragments to classify the locus into three groups according to Bell's method (a short, class 1 allele...

Topics

Adult
Alleles
DNA
DNA Restriction Enzymes
DNA Transposable Elements
Diabetes Mellitus
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
Gene Frequency
Genes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Insulin

Japan

Leukocytes

Male

Obesity

Source

Open in PubMed

Identifiers

PMID: 3017653
DOI: 10.2337/diacare.9.4.365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3017653-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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