Article
Islet amyloid polypeptide (IAPP) gene analysis in a Japanese diabetic with marked islet amyloid deposition.
Diabetes research and clinical practice - 1 Jan 1992
Kajio H, Kobayashi T, Hara M, Nakanishi K, Sugimoto T, Murase T, Akanuma Y, Kosaka K, Shibasaki Y, Kasuga M
Abstract excerpt
Islet amyloid polypeptide (IAPP) is a major constituent of pancreatic amyloid deposits in many patients with non-insulin-dependent diabetes mellitus (NIDDM). We analyzed the IAPP gene in a Japanese diabetic with marked islet amyloid deposition. Pancreatic specimens were obtained from an 87-year-o...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Amino Acid Sequence
- Amyloid
- Axons
- Chromosome Deletion
- Diabetes Mellitus, Type 2
- Humans
- Islet Amyloid Polypeptide
- Islets of Langerhans
- Japan
- Male
- Mutation
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid