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Article

A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).

The Journal of clinical investigation - 1 Jun 1992

Yano H, Kitano N, Morimoto M, Polonsky K S, Imura H, Seino Y

Abstract excerpt

We have identified a 65-yr-old nonobese Japanese man with diabetes mellitus, fasting hyperinsulinemia (150-300 pM), and a reduced fasting C-peptide/insulin molar ratio of 2.5-3.0. Fasting hyperinsulinemia was also found in his son and daughter. Analysis of insulin isolated from the serum of the proband and his son by reverse-phase high performance liquid chromatography revealed a minor peak coeluting with human...

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Identifiers

PMID: 1601997
DOI: 10.1172/JCI115795
PMCID: PMC295889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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