Article
Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity.
Biochimica et biophysica acta - 1 Dec 2011
Ivanov Igor, Di Venere Almerinda, Horn Thomas, Scheerer Patrick, Nicolai Eleonora, Stehling Sabine, Richter Constanze, Skrzypczak-Jankun Ewa, Mei Giampiero, Maccarrone Mauro, Kühn Hartmut
Abstract excerpt
12/15-Lipoxygenases (12/15-LOXs) have been implicated in inflammatory and hyperproliferative diseases but the structural biology of these enzymes is not well developed. Most LOXs constitute single polypeptide chain proteins that fold into a two-domain structure. In the crystal structure the two domains are tightly associated, but small angle X-ray scattering data and dynamic fluorescence studies suggested a high...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.