Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15.

doi:10.3390/ijms22063285

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Article

Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15.

International journal of molecular sciences - 23 Mar 2021

Ivanov Igor, Cruz Alejandro, Zhuravlev Alexander, Di Venere Almerinda, Nicolai Eleonora, Stehling Sabine, Lluch José M, González-Lafont Àngels, Kuhn Hartmut

Abstract excerpt

Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. In the presence of an active site ligand (the ALOX15 inhibitor RS7) rabbit ALOX15 was crystalized as heterodimer and the X-ray coordinates of the two monomers within the dimer exhibit subtle structural...

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PMID: 33807076
DOI: 10.3390/ijms22063285
PMCID: PMC8004969

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