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Article

Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?

Proteins - 1 Mar 2012

Ivanov Igor, Shang Weifeng, Toledo Lea, Masgrau Laura, Svergun Dmitri I, Stehling Sabine, Gómez Hansel, Di Venere Almerinda, Mei Giampiero, Lluch José M, Skrzypczak-Jankun Ewa, González-Lafont Angels, Kühn Hartmut

Abstract excerpt

Mammalian lipoxygenases (LOXs) have been implicated in cellular defense response and are important for physiological homeostasis. Since their discovery, LOXs have been believed to function as monomeric enzymes that exhibit allosteric properties. In aqueous solutions, the rabbit 12/15-LOX is mainly present as hydrated monomer but changes in the local physiochemical environment suggested a monomer-dimer...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Crystallography, X-Ray

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Source

Identifiers

PMID: 22189720
DOI: 10.1002/prot.23227

Genes

LOX

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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