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Article

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

The Biochemical journal - 14 Dec 2009

Esser Julia, Rakonjac Marija, Hofmann Bettina, Fischer Lutz, Provost Patrick, Schneider Gisbert, Steinhilber Dieter, Samuelsson Bengt, Rådmark Olof

Abstract excerpt

The activity of 5-LO (5-lipoxygenase), which catalyses two initial steps in the biosynthesis of pro-inflammatory LTs (leukotrienes), is strictly regulated. One recently discovered factor, CLP (coactosin-like protein), binds 5-LO and promotes LT formation. In the present paper we report that CLP a...

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Source

Identifiers

PMID: 19807693
DOI: 10.1042/BJ20090856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19807693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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