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Article

Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering.

Journal of molecular biology - 17 Jun 2011

Shang Weifeng, Ivanov Igor, Svergun Dmitri I, Borbulevych Oleg Y, Aleem Ansari M, Stehling Sabine, Jankun Jerzy, Kühn Hartmut, Skrzypczak-Jankun Ewa

Abstract excerpt

Human lipoxygenases (LOXs) and their metabolites have a great impact on human homeostasis and are of interest for targeted drug design. This goal requires detailed knowledge of their structures and an understanding of structure-function relationship. At the moment, there are two complete crystal structures for mammalian LOX [rabbit 12/15LOX (r-12/15LOX) and human 5LOX (h-5LOX)] and a fragment of human 12LOX. The...

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Source

Identifiers

PMID: 21530540
DOI: 10.1016/j.jmb.2011.04.035

Genes

LOX
PLAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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