Article
Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis.
Chemistry & biology - 1 Aug 2001
Walther M, Ivanov I, Myagkova G, Kuhn H
Abstract excerpt
BACKGROUND: Mammalian lipoxygenases (LOXs) are categorised with respect to their positional specificity of arachidonic acid oxygenation. However, the mechanistic basis for this classification is not well understood. To gain a deeper insight into the structural basis of LOX specificity we determined the reaction characteristics of wild-type and mutant mammalian LOX isoforms with native and synthetic fatty acids...
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