Article
Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.
Biochimica et biophysica acta - 1 Dec 2013
Horn Thomas, Ivanov Igor, Di Venere Almerinda, Kakularam Kumar Reddy, Reddanna Pallu, Conrad Melanie L, Richter Constanze, Scheerer Patrick, Kuhn Hartmut
Abstract excerpt
Mammalian lipoxygenases belong to a family of lipid-peroxidizing enzymes, which have been implicated in cardiovascular, hyperproliferative and neurodegenerative diseases. Here we report that a naturally occurring mutation in the hALOX15 gene leads to expression of a catalytically near-null enzyme variant (hGly422Glu). The inactivity may be related to severe misfolding of the enzyme protein, which was concluded...
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