Article
Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.
Chemical research in toxicology - 21 Nov 2011
Duysen Ellen G, Koentgen Frank, Williams Gareth R, Timperley Christopher M, Schopfer Lawrence M, Cerasoli Douglas M, Lockridge Oksana
Abstract excerpt
The LD(50) for soman is 10-20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse but not in human plasma. Our goal was to make a mouse lacking plasma carboxylesterase. We used homologous recombination to inactivate the carboxylesterase ES1 gene on mouse chromosome 8 by deleting exon 5 and by introducing a frame shift for amino acids...
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