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Article

Neuropathy target esterase (NTE): overview and future.

Chemico-biological interactions - 25 Mar 2013

Richardson Rudy J, Hein Nichole D, Wijeyesakere Sanjeeva J, Fink John K, Makhaeva Galina F

Abstract excerpt

Neuropathy target esterase (NTE) was discovered by M.K. Johnson in his quest for the entity responsible for the striking and mysterious paralysis brought about by certain organophosphorus (OP) esters. His pioneering work on OP neuropathy led to the view that the biochemical lesion consisted of NTE that had undergone OP inhibition and aging. Indeed, nonaging NTE inhibitors failed to produce disease but protected...

Topics

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Carboxylic Ester Hydrolases
Catalytic Domain
Gene Knockout Techniques
History, 20th Century
History, 21st Century

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Neuron Disease

Neurotoxicity Syndromes

Organophosphorus Compounds

Source

Identifiers

PMID: 23220002
DOI: 10.1016/j.cbi.2012.10.024

Genes

PNPLA1
PNPLA6
PNPLA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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